团队负责人
董庆利
团队成员
李卓思、王翔、刘阳泰、马悦、秦晓杰、夏雪娟
团队简介
研究团队主要从事食品微生物安全与风险防控领域，研究方向主要包括以下几个方面：（1）食源性致病菌检测、监测与分子溯源；（2）食源性致病菌预测建模、风险评估及软件工具开发；（3）食源性致病菌-宿主互作致病机制解析；（4）食品微生物防控技术研发与应用
代表性成果
1.科研项目
[1] 2025-2028，国家自然科学基金-面上项目，冰淇淋中单增李斯特菌模块化过程风险模型构建研究
[2] 2024-2027，国家重点研发计划“政府间国际科技创新合作”重点专项，基于新型细胞模型的重要食源性致病菌与宿主细胞互作机制研究
[3] 2023-2025，国家自然科学基金-青年基金项目，基于器官芯片技术的单增李斯特菌靶向及穿越胎盘屏障机制研究
[4] 2023-2025，国家自然科学基金-青年基金项目，纤维素基光杀菌纳米纤维膜的构建及其杀菌食品包装应用的研究
[5] 2022-2024，国家自然科学基金-青年基金项目，硫酯酶YbgC调控肠炎沙门氏菌抵抗蛋清溶菌酶胁迫的分子机制
[6] 2022-2024，国家自然科学基金-青年基金项目, 联合定殖与转移模型的厨房食品接触表面单增李斯特菌暴露评估研究
[7] 2019-2021，国家自然科学基金-青年基金项目，单增李斯特菌在模拟热加工和冷藏过程中的生态行为模型构建及机制研究
[8] 2013-2016，国家自然科学基金-面上项目，基于预测微生物学理论的肉类风险评估基础研究
[9] 2009-2011，国家自然科学基金-青年项目，冷却猪肉中腐败菌的预测模型统一化研究
[10] 2025-2028，宁夏回族自治区重点研发计划子课题，滩羊新现病原流行监测预警及绿色防控关键技术研究与示范
[11] 2025-2028，上海市农业科技创新项目-春蕾计划，酵母微胶囊技术对即食果蔬中重要致病菌的绿色防控应用研究
[12] 2023-2026，2023年度上海市农业科技创新项目，畜禽关键环节单增李斯特菌风险监测与评估防控的贝叶斯网络构建应用示范
[13] 2022-2025，上海市农业农村委员会-农业科技创新技术培育项目，食用香草中重要致病菌控制技术研究与应用
[14] 2024-2025，上海市疾病预防控制中心-食品安全风险专题评估项目, 上海市禽肉中空肠弯曲菌定量风险评估
[15] 2024-2025，上海市疾病预防控制中心-食品安全风险专题评估项目, 食用油脂制品中主要污染物风险评估
[16] 2025-2025，上海市卫生健康委员会-食品安全风险评估项目，奶酪、鲜果切等即食食品中单增李斯特菌污染和疾病负担评估
[17] 2022-2024，上海市卫生健康委员会-食品安全风险评估项目，食源性单增李斯特菌耐药性与毒力相关性研究
[18] 2021-2024，2021年度上海市科技兴农技术创新项目，即食果蔬中致病菌风险监测及建模评估研究
[19] 2024-2024，上海市疾病预防控制中心-食品安全风险专题评估项目，不同 ST 型单增李斯特菌定量风险评估及其致病潜力分级
[20] 2020-2021，上海市疾病预防控制中心-食品安全风险专题评估项目, 快速定量微生物风险评估平台
2.发明专利
[1]张希斌，张一敏，董庆利，孙春华等；一种抗生素定量检测装置及使用方法，ZL 202210819170.7
[2]马悦，李柯欣，李朝霞，茹义博，董庆利，李卓思，王翔；一种光敏环糊精纳米海绵及其制备方法及应用，CN202311824445.7
[3]马悦，茹义博，李柯欣，郑好，董庆利，王翔，刘阳泰；一种光敏纳米纤维膜及其制备方法与应用，CN202410571323.X
[4]马悦，李柯欣，董庆利；李卓思，夏雪娟，秦晓杰；可见光驱动广谱杀菌纳米纤维膜及其制备方法与应用，CN202510611475.2
[5]马悦，董庆利，郑好，王翔， 刘阳泰，李柯欣；一种淀粉样蛋白基光敏涂层材料及其制备方法与应用，CN 202510194099.1
[6]李卓思，董庆利，高彬茹，闫辉；野生型ST87单增李斯特基因缺失菌株及其制备方法，CN202510315722.4
[7]秦晓杰，刘婷宇，董庆利；一种多重耐药沙门氏菌烈性噬菌体及其应用，CN202411396670.X
[8]秦晓杰，刘婷宇，薛嘉怡，董庆利，王翔，李卓思；一种曼哈顿沙门氏菌噬菌体及其应用，CN202510191685.0
3.科技成果奖
[1]2016，上海市科学技术奖二等奖
[2]2020，浙江省农业厅技术进步奖二等奖
[3]2021, 海关总署2021年度海关科技成果一等奖
[4]2022，江苏省农学会技术创新奖（2022年度进步与发明类）一等奖
4.学术论文
[1] Ampicillin-induced resistant variants of Listeria monocytogenes: effects on growth, survival, and virulence. Food Research International, 2025, 221, 117537.
[2] Quantitative risk assessment of Listeria monocytogenes in cooked meat products from retail to consumption in China. Food Control, 2025, 178,111499.
[3] Stresses in the food chain and their impact on antibiotic resistance of foodborne pathogens: A review. Food Microbiology，2025,128,104741.
[4] Development of an on-site real-time dual detection method for norovirus and rotavirus using RPA-CRISPR/Cas12,13.Food Control，2025,168,110943.
[5] Comparative genomics analysis of Salmonella Enteritidis isolated from clinical cases associated with chicken. BMC Microbiology,2024,24,497.
[6] Covalent binding of vitamin K3 photosensitizers to nanofibrous membranes for daylight-driven antimicrobial applications. Chemical Engineering Journal, 2025，166068.
[7] Advancements in photodynamic inactivation: A comprehensive review of photosensitizers, mechanisms, and applications in food area. Comprehensive Reviews in Food Science and Food Safety, 2025, 24(2), e370127.
[8] Edible antimicrobial yeast-based coating with basil essential oil for enhanced food safety. Innovative Food Science & Emerging Technologies, 2024, 93, 103612.
[9] Soybean Protein Isolate-Incorporated Zwitterionic Hydrogel with Rapid Chlorine Rechargeable Biocidal and Antifouling Functions. ACS Sustainable Chemistry & Engineering, 2023, 11(34), 12843-12852.
[10] Isolation and characterization of Salmonella Typhimurium monophasic variant phage and its application in foods. Food Research International, 2025, 203: 115852.
[11] Characterization of a novel Salmonella enterica serovar Manhattan phage and its inhibitory effects in vitro and in food matrices. LWT-Food Science and Technology, 2025, 222: 117617.
[12] Characterization of a novel lytic Mooglevirus phage to control Salmonella
Senftenberg and its application in foods. Food Control, 2026, 182: 111853.
[13] Prevalence, antibiotic resistance, resistance and virulence determinants of Campylobacter jejuni in China: A systematic review and meta-analysis. One Health, 2025, 20: 100990.
[14] Causal inference in food safety: methods, applications, and future prospects. Trends in Food Science and Technology, 2025, 155: 104805.
[15] pLM33 provides tolerance of persistent Listeria monocytogenes ST5 to various stress conditions and also enhances its virulence. Food Microbiology, 2025, 126: 104675.
[16] Molecular characteristics of florfenicol-resistant Salmonella based on whole-genome sequencing. LWT, 2025, 216: 117323.
[17] Impact of temperature fluctuation on biofilm formation and removal of different Listeria monocytogenes strains in ice cream processing environments. Food Research International, 2025, 221: 117416.
[18] Evaluation of the virulence characteristics of ST11 Salmonella enterica from different sources using a 2D cell model. International Journal of Food Microbiology, 2025, 434: 111151.
[19] Elucidating the biofilm formation process, microstructure and functional gene expression of Listeria monocytogenes in beef juice. International Journal of Food Microbiology, 2025, 434: 111160.
[20] Transcriptome analysis of mature biofilm and planktonic cells of Listeria monocytogenes under nutritional stress. Food Microbiology, 2025, 132: 104859.
[21] Advancing microbial risk assessment: perspectives from the evolution of detection technologies. npj Science of Food, 2025, 9: 157.
[22] Analysis and probabilistic simulation of Listeria monocytogenes inactivation in cooked beef during unsteady heating, International Journal of Food Science & Technology, 2021, 56(5): 2282-2290.
[23] Employing genome-wide association studies to investigate acid adaptation mechanisms in Listeria monocytogenes, Food Research International, 2024, 196：115106
[24] The prevalence of Listeria monocytogenes in meat products in China: A systematic literature review and novel meta-analysis approach, International Journal of Food Microbiology, 2020, 312: 108358
[25] Advancements in Nucleic Acid-based Enumeration Methods for Viable Foodborne Pathogenic Bacteria. Current Opinion in Food Science, 2025, 61: 101254
[26] Impact of whole grain highland hull-less barley on the denaturing gradient gel electrophoresis profiles of gut microbial communities in rats fed high-fat diets. Microbiology Spectrum. 2024, 12(6): e0408923.
[27] Endothelial Progenitor Cells as an Emerging Cardiovascular Risk Factor in the Field of Food and Nutrition Research: Advances and Challenges. Critical Reviews in Food Science and Nutrition. 2023, 21:1-18.
[28] Survival and virulence changes in antibiotic-resistant and sensitive Listeria monocytogenes after consecutive gastrointestinal exposure, LWT, 2025,216(117330)
[29] Effects of nisin and sesamol on biofilm formation and virulence of Listeria monocytogenes, Food Control, 2024, 160: 110348
[30] Growth, biofilm formation, and motility of Listeria monocytogenes strains isolated from food and clinical samples located in Shanghai (China), Food Research International, 2024,184：114232
